Spravato® Music Guide

The Right Music Changes Everything.

Spravato® creates a state of deep inner openness. The music you choose during treatment isn't background noise — it's an active part of the therapeutic process. This guide helps you choose wisely.

Why it matters

Why Music Selection Matters

Research in esketamine-assisted therapy consistently shows that music influences the emotional tone, depth, and integration of the experience. The wrong music can create anxiety or distraction. The right music can provide structure, safety, and a pathway into meaningful inner work.

This guide draws on music therapy principles, clinical research, and the lived experience of Spravato® patients to give you a practical framework for building your listening practice.

Foundations

Core Principles for Spravato® Music

01

Avoid lyrics (especially early sessions)

Lyrics engage the language-processing mind and can pull you out of the inner experience. Instrumental music — or music with minimal, non-English, or chant-like vocals — tends to support deeper states.

02

Choose music with emotional arc

The best session music moves through phases: gentle opening, deeper exploration, and a soft return. A single-mood playlist can feel monotonous or stuck. Look for music that breathes and evolves.

03

Familiar but not distracting

Music you know well can feel safe and grounding. Music that's completely unfamiliar can be disorienting. A middle path — music you've heard a few times but don't know by heart — often works best.

04

Match the session phase

Spravato® sessions have distinct phases: onset (first 20–30 min), peak (30–60 min), and integration (final 30 min). Different music qualities serve each phase. See our phase-by-phase guide below.

Session structure

Music by Session Phase

Phase 1

Onset (0–30 min)

Gentle, grounding, minimal. Help the mind settle and release resistance.

Good genres:

AmbientDroneSlow classicalNature sounds with music

Avoid: Sudden tempo changes, complex rhythms, familiar pop songs

Phase 2

Peak (30–60 min)

Emotionally rich, expansive, supportive of deep inner exploration.

Good genres:

OrchestralPost-classicalPsychedelic ambientSacred choral

Avoid: Jarring transitions, aggressive dynamics, lyrics with strong narrative

Phase 3

Integration (60–90 min)

Gentle return. Warm, grounding, soft. Help the mind re-orient.

Good genres:

Acoustic guitarSoft pianoFolk ambientGentle world music

Avoid: High energy, complex arrangements, anything that demands attention

Now available

The Listening to Spravato® Book

Genre guides, session playlists, and the science of music-assisted healing — by Justin Page

Get the Book

Now available

The Listening to Spravato® Book

By Justin Page — genre guides, session playlists, and the science of music-assisted healing

Get the Book
Listening to Spravato®

A guide to using sound intentionally during Spravato® treatment — for patients, clinicians, and caregivers seeking deeper healing through music.

Not medical advice. Justin Page is a conservatory-trained musician (Manhattan School of Music; Berklee College of Music), Presidential Scholar, and Spravato® patient who has undergone more than 80 documented esketamine treatment sessions. His work on music and esketamine neuroscience has been reviewed by clinical collaborators and submitted to the treatment manufacturer for feedback and verification. Content on this site reflects personal clinical experience, independent research, and ongoing collaboration with licensed mental health professionals — it does not constitute medical advice and is not a substitute for guidance from your prescriber, therapist, or care team. Always consult your treating clinician before making any changes to your treatment protocol.

© 2026 Listening to Spravato®. All rights reserved.

Spravato® is a registered trademark of Janssen Pharmaceuticals, Inc., which is part of Johnson & Johnson.